Strychnos pseudoquinaand Its Purified Compounds Present an EffectiveIn VitroAntileishmanial Activity
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چکیده
منابع مشابه
Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity
The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazone...
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Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol (14) and 24-hydroperoxy-24-vinylcholesterol (15), with IC(50) values of 7.8 +/- 1.2 and 3.2 +/- 1.2 microM, respectively. The...
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In considération of thé many biological properties of alkaloids, and particularly of quinine (which remains an important antimalarial drug), it was not surprising that a séries of indolomonoterpenic alkaloids, mainly isolated from Strychnos usambarensis Gilg and from Strychnos icaja Baill., thé latter used in traditional medicine from Central Africa to treat chronic malaria, présent antiplasmod...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2013
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2013/304354